Arimidex is the trade name of Anastrozole being marketed by Astra Zeneca. It is a drug used for the treatment of breast cancer post surgery and for metastases in both pre and post menopausal conditions in women. Arimidex is an aromatic inhibitor. An aromatic inhibitor is a substance that breaks up a crucial step in the body during the synthesis of estrogen. Using this whilst on cycle completely blocks the activity and side effects of aromatized testosterone.
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Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class. It is the world’s most widely consumed psychoactive drug. Unlike many other psychoactive substances, it is legal and unregulated in nearly all parts of the world. There are several known mechanisms of action to explain the effects of caffeine. The most prominent is that it reversibly blocks the action of adenosine on its receptors and consequently prevents the onset of drowsiness induced by adenosine. Caffeine also stimulates certain portions of the autonomic nervous system.
Caffeine is a bitter, white crystalline purine, a methylxanthine alkaloid, and is chemically related to the adenine and guanine bases of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). It is found in the seeds, fruits, nuts, or leaves of a number of plants native to Africa, East Asia and South America, and helps to protect them against herbivores and from competition by preventing the germination of nearby seeds, as well as encouraging consumption by select animals such as honey bees. The best-known source of caffeine is the coffee bean, the seed of the Coffea plant. People may drink beverages containing caffeine to relieve or prevent drowsiness and to improve cognitive performance. To make these drinks, caffeine is extracted by steeping the plant product in water, a process called infusion. Caffeine-containing drinks, such as coffee, tea, and cola, are consumed globally in high volumes. In 2020, almost 10 million tonnes of coffee beans were consumed globally.
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Clomifene or Clomiphene (also known as Clomifert), marketed as Clomid, is a selective estrogen receptor modulator (SERM) that increases production of gonadotropins by inhibiting negative feedback on the hypothalamus. Clomid inhibits estrogen receptors in the hypothalamus, thereby inhibiting negative feedback of estrogen on gonadotropin production. It may also result in direct stimulation of the hypothalamic pituitary adrenal axis. In short, Clomid provides the bodybuilder with a controlled and dependable post cycle treatment specifically in the return of the testicles to normal size and function (it brings your balls back).
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Cytomex T350 (Cytomel) is the popularly recognized brand name for the drug Liothyronine Sodium. This is not an anabolic steroid but a thyroid hormone. It is used medically to treat cases of thyroid insufficiency, obesity, certain metabolic disorders and fatigue. Specifically, this drug is a pharmaceutical preparation of the natural thyroid hormone Triiodothyronine (T-3). When administered, Cytomex T350 increases the patient’s metabolism. The result is an increased rate of cellular activity (noted by a more rapid utilization of carbohydrates, fats and proteins).
Bodybuilders are particularly attracted to this drug for its ability to burn off body excess fat. Most often utilized during contest preparation, one can greatly decrease the amount of stored fat without being forced to severely restrict calories. To this end Cytomex T350 is commonly used in conjunction with Clenbuterol and can produce extremely dramatic results. This combination has become very popular in recent years, no doubt responsible for many “ripped” on-stage physiques. It is also noted by many that when thyroid hormones are taken in conjunction with steroids, an increased anabolic effect can be seen (noticeably greater than if the steroids are used alone). This is likely due to faster utilization of proteins by the body, increasing the rate for new muscle accumulation.
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Duromine – Phentermine, a contraction of “phenyl-tertiary-butylamine”, is a psychostimulant drug of the substituted amphetamine chemical classes, with pharmacology similar to amphetamine. It is used medically as an appetite suppressant.
Duromine is approved in Australia as an appetite suppressant and is medically prescribed as a diet pill; intended for obese patients and patients that are considered a medical risk due to weight. Duromine is a prescription that helps aid weight-loss and is designed for short-term use with a combination of exercise and a healthy diet. In the USA, phentermine is FDA approved.
The long half-life (22 hours) of Duromine makes it an ideal appetite suppressant choice with manageable side effects. Ideal dosing is 36mg once daily each morning and increasing as you get used to the effects since most users liken it to ‘legal speed’.
Duromine may be habit-forming. Never share phentermine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. FDA pregnancy category X. Weight loss during pregnancy can harm an unborn baby, even if you are overweight. Do not use phentermine if you are pregnant.
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Enclomiphene is used to raise serum total testosterone levels while maintaining sperm counts in the normal range in men with secondary hypogonadism. Use of 12.5-50mg mg enclomiphene citrate daily significantly increased total T levels in hypogonadal men, with an efficacy that was comparable to topical testosterone. Increases in LH and FSH levels also were found with enclomiphene citrate treatment.
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Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, Hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist.
Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting. However, Tamoxifen is popular with anabolic steroid users to reduce the build up of breast tissue (gynecomastia) caused by the excess aromatization of testosterone to estrogen.
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Mechanism of action of Yohimbine
Yohimbine is a naturally occurring fat-burning compound derived from the bark of an African tree. Primarily used to aid fat loss during short term fasting, Yohimbine is also an aphrodisiac, vasodilator and can aid erectile dysfunction (PDE5 Inhibitor).
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